Structural Investigations on Isolated Chromatin of Higher-Order Organisation
نویسندگان
چکیده
منابع مشابه
On key modulators of higher-order chromatin structure
The billions of DNA bases that comprise mammalian genomes encode the instructions to assemble complex organisms consisting of hundreds of different cell types. Apart from the challenge of packaging this genetic material into a nuclear space that is six orders of magnitude smaller than its linear sequence, the molecules need to be organised in such a way as to ensure the coordinated activity of ...
متن کاملNucleosome spacing and chromatin higher-order folding
Packing of about two meters of the human genome DNA into chromatin occupying a several micron-sized cell nucleus requires a high degree of compaction in a manner that allows the information encoded on DNA to remain easily accessible. This packing is mediated by repeated coiling of DNA double helix around histones to form nucleosome arrays that are further folded into higher-order structures. Re...
متن کاملMethods for identifying higher-order chromatin structure.
Eukaryotic genomic DNA is combined with histones, nonhistone proteins, and RNA to form chromatin, which is extensively packaged hierarchically to fit inside a cell's nucleus. The nucleosome-comprising a histone octamer with 147 base pairs of DNA wrapped around it-is the initial level and the repeating unit of chromatin packaging, which electron microscopy first made visible to the human eye as ...
متن کاملChromatin higher-order structure and dynamics.
The primary role of the nucleus as an information storage, retrieval, and replication site requires the physical organization and compaction of meters of DNA. Although it has been clear for many years that nucleosomes constitute the first level of chromatin compaction, this contributes a relatively small fraction of the condensation needed to fit the typical genome into an interphase nucleus or...
متن کاملHigher-Order Chromatin Regulation of Inflammatory Gene Expression
Whether it is caused by viruses and bacteria infection, or low-grade chronic inflammation of atherosclerosis and cellular senescence, the transcription factor (TF) NF-κB plays a central role in the inducible expression of inflammatory genes. Accumulated evidence has indicated that the chromatin environment is the main determinant of TF binding in gene expression regulation, including the stimul...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2005
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1981.tb06381.x